Key Brain Proteins in AD

Alzheimer's disease is characterized by the abnormal accumulation and dysfunction of specific brain proteins, with SORLA emerging as a potential protective factor.

The top 3

  1. Amyloid-Beta Protein: Amyloid-beta is a protein fragment that, in Alzheimer's, misfolds and aggregates into plaques outside neurons, disrupting cell communication and contributing to neurodegeneration.
  2. Tau Protein's Dual Role: Tau normally stabilizes microtubules inside neurons, but in Alzheimer's, it forms toxic neurofibrillary tangles that disrupt cellular transport and spread through the brain, leading to cell death and memory loss.
  3. SORLA's Protective Functions: SORLA is a sorting receptor that helps reduce amyloid-beta production and accumulation, protects against toxic tau tangles, and regulates lysosome function in brain cells, acting as a shield against Alzheimer's pathology.

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