First PLP-dependent enzyme that influences bacterial protein production discovered

Researchers from the Singapore-MIT Alliance for Research & Technology's (SMART) Antimicrobial Resistance (AMR) interdisciplinary research group, alongside collaborators from Massachusetts Institute of Technology (MIT), Nanyang Technological University (NTU Singapore), and institutions in the United States, Poland and France, have discovered aminovaleramididi

The top 3

  1. Discovery of Ribosomes as Cellular Protein Factories: George E. Palade discovered ribosomes in 1955, initially naming them 'Palade particles,' and was later awarded the Nobel Prize in Physiology or Medicine in 1974 for identifying these tiny cellular structures as the primary sites of protein synthesis. George E. Palade
  2. Elucidation of the Genetic Code: Marshall Nirenberg and Heinrich Matthaei deciphered the first codon, UUU for phenylalanine, in 1961, and by 1966, along with Har Gobind Khorana and Robert Holley, the entire genetic code was cracked, revealing how DNA's four-letter alphabet dictates the 20 amino acids in proteins. Marshall Nirenberg
  3. Identification of Messenger RNA (mRNA): In 1961, Sydney Brenner, François Jacob, and Matthew Meselson, along with François Gros, experimentally demonstrated the existence of messenger RNA (mRNA) as an unstable intermediate molecule that carries genetic instructions from DNA to ribosomes for protein synthesis. Sydney Brenner

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